Researchers at Uppsala University in Sweden have developed a new responsive coating for implants used in surgery to improve their integration into bone and to prevent rejection.
The study, published in Advanced Engineering Materials, shows that gels made by modifying hyaluron can be used to coat implants, and the coated titanium surfaces can bind protein molecules which promote bone formation. These can be released slowly once the surface comes in contact with a solution of calcium ions.
“We envisage that the materials will be used in medicine to modulate the healing process in bone,” says Associate Professor Dmitri Ossipov.
“Neutrons are an ideal tool to understand the interactions of metal surfaces, polysaccharide biopolymers, and proteins thanks to a contrast matching technique that highlights only the protein components at the interface.”