A powerful new antiseptic agent, called ozone nano-bubble water, holds promise for the treatment of periodontitis, or severe gum infections, according to research published in the journal Science and Technology of Advanced Materials.
The study, by Shinichi Arakawa and colleagues at Tokyo Medical and Dental University and Japan's National Institute of Advanced Industrial Science and Technology, evaluated the bactericidal activities of ozone nano-bubble water -- also known as NBW3 -- against the two main bacterial agents that cause periodontitis as well as its toxicity to human oral tissue cells.
Their results showed that NBW3 can kill periodontal pathogens within 30 seconds of exposure, yet has only a minor impact on the viability of oral tissue cells after 24 hours of exposure.
Based on their in vitro results, the researchers conclude that NBW3 could become a valuable tool for treating periodontitis. However, since in vitro models cannot be directly compared to real-life clinical situations in which oral antiseptics are diluted with saliva, the authors recommend further research to determine the extent to which NBW3's potency may be reduced by the saliva of dental patients.
Image: Changes in the microstructure of bacterial cells exposed to NBW3 were assessed using a transmission electron micrograph (TEM). In Escherichia coli cells exposed to NBW3, disruption of the cell wall and the presence of numerous membrane vesicles projecting from the cell wall were observed (A). Moreover, coagulated materials were seen inside the treated cells, in particular, close to the cell membrane (B). Credit: National Institute for Materials Science